QuickView for Cry1 (gene)
- Gene Symbol:
- CRY1
Homo sapiens - Full name:
- cryptochrome circadian regulator 1
- Synonyms:
- DSPD, PHLL1, cryptochrome-1, cryptochrome 1 (photolyase-like), cryptochrome circadian clock 1
- Genomic Location:
- Chr 12: 105909272-106011455
- Description:
-
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CGTSACG_PAX3_B , RTAAACA_FREAC2_01 , NFAT_Q6 , AML_Q6 , ZF5_01 , YATTNATC_UNKNOWN , PAX3_01 , AML1_01 , AR_Q6 , TCTGATA_MIR361
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q23.3
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | DNA (6-4) photolyase activity | hormone receptor binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | nucleotide binding | signaling receptor binding | blue light photoreceptor activity | lyase activity | carbon-carbon lyase activity | catalytic activity | DNA photolyase activity | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | photoreceptor activity | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | deoxyribodipyrimidine photo-lyase activity | RNA polymerase II regulatory region sequence-specific DNA binding | phosphatase binding | histone deacetylase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | negative regulation of G-protein coupled receptor protein signaling pathway | response to radiation | regulation of localization | response to hormone | lipid storage | negative regulation of cellular process | negative regulation of RNA biosynthetic process | glucose metabolic process | glucose homeostasis | regulation of lipid transport | cellular process | circadian regulation of gene expression | localization | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | negative regulation of glucocorticoid secretion | macromolecule localization | negative regulation of secretion | regulation of cell cycle | negative regulation of hormone secretion | negative regulation of cellular metabolic process | response to peptide hormone | DNA damage induced protein phosphorylation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | negative regulation of glucocorticoid receptor signaling pathway | response to stimulus | cellular response to light stimulus | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | negative regulation of circadian rhythm | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | blue light photoreceptor activity | response to peptide | circadian rhythm | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of transport | negative regulation of metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | response to light stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of hormone levels | regulation of hormone secretion | blue light signaling pathway | regulation of gene expression | cellular response to stress | hexose biosynthetic process | cellular response to radiation | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | regulation of transcription by RNA polymerase II | negative regulation of intracellular steroid hormone receptor signaling pathway | carbohydrate biosynthetic process | regulation of DNA damage checkpoint | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | carbohydrate metabolic process | protein phosphorylation | phosphate-containing compound metabolic process | response to blue light | cell communication | regulation of cellular metabolic process | cellular response to blue light | regulation of endocrine process | regulation of protein metabolic process | homeostatic process | regulation of RNA metabolic process | negative regulation of protein ubiquitination | negative regulation of lipid transport | response to glucagon | protein metabolic process | response to organic substance | response to insulin | entrainment of circadian clock | metabolic process | lipid localization | regulation of RNA biosynthetic process | hexose metabolic process | negative regulation of transcription, DNA-templated | chemical homeostasis | regulation of secretion | gluconeogenesis | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | transcription, DNA-templated | intracellular receptor signaling pathway | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of circadian rhythm | regulation of G-protein coupled receptor protein signaling pathway | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | entrainment of circadian clock by photoperiod | response to organonitrogen compound | photoperiodism | heterocycle metabolic process | cellular metabolic process | carbohydrate homeostasis | protein-chromophore linkage | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | intracellular
