QuickView for Ctnnb1 (gene)

Gene Symbol:

CTNNB1 Homo sapiens

Full name:

catenin beta 1

Synonyms:

CTNNB, EVR7, MRD19, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa

Genomic Location:

Chr 3: 41215946-41256943

Description:

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inh...

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The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

STAT4_01 ,  TTTGCAG_MIR518A2 ,  HOXA4_Q2 ,  AML_Q6 ,  STAT6_02 ,  GCTGAGT_MIR5125P ,  SOX9_B1 ,  CAGCTTT_MIR320 ,  CTTTAAR_UNKNOWN ,  SOX5_01 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  SRY_02 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-381

Cytogenetic Map:

3p22.1

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