QuickView for Cxcl12 (gene)

Gene Symbol:

CXCL12 Homo sapiens

Full name:

C-X-C motif chemokine ligand 12

Synonyms:

IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, stromal cell-derived factor 1, chemokine (C-X-C motif) ligand 12, intercrine reduced in hepatomas, pre-B cell growth-stimulating factor

Genomic Location:

Chr 10: 44185611-44200548

Description:

This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue h...

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This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGTGTT_MIR141_MIR200A ,  ATCTTGC_MIR31 ,  TAATGTG_MIR323 ,  CAGGTG_E12_Q6 ,  ATACTGT_MIR144 ,  AATGTGA_MIR23A_MIR23B ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  CCANNAGRKGGC_UNKNOWN ,  SP1_Q6_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-421

miRNA binding sites
(Source: miRecords):

hsa-miR-23a Targeted Genes

Cytogenetic Map:

10q11.21

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