Name: | Cyclophosphamide |
---|---|
PubChem Compound ID: | 22420 |
Description: | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. |
Molecular formula: | C7H17Cl2N2O3P |
Molecular weight: | 279.101 g/mol |
Synonyms: |
Cyclophosphamide (USP); CCRIS 7469; Cyclophosphamide (hydrated); 2H-1,3,2-Oxazaphosphorine, tetrahydro-2-(bis(2-chloroethyl)amino)-, 2-oxide, monohydrate; 2-(Bis(2-chloroethyl)amino)-1-oxa-3-aza-2-phosphocyclohexane 2-oxide monohydrate; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate; Cyclophosphamide hydrate (JP15); alkylating agent: crosslinks DNA; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorin-2-amine, 2-oxide monohydrate; N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate.
show more » |
Name: | Cyclophosphamide |
---|---|
Name (isomeric): | DB00531 |
Drug Type: | small molecule |
Description: | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. |
Brand: | Cyclophosphane, Cyclophosphoramide, Endoxane, Procytox, Endoxana, Cyclostin, Lyophilized Cytoxan, Sendoxan, ASTA, Neosar, Senduxan, Asta B 518, Clafen, Endoxanal, Genoxal, Semdoxan, Cytophosphan, Mitoxan, CY, Endoxan-Asta, Cytoxan, Cyclophosphamidum, Claphene, Endoxan R, Rcra Waste Number U058, Hexadrin, Cyclophosphamide Monohydrate, Cyklofosfamid, Cyclophosphamide Sterile, Zyklophosphamid, Revimmune, CPA, CTX, Endoxan, CP, Cyclophosphan, Cyclophosphamid, Cytoxan Lyoph, Enduxan |
Brand name mixture: | Procytox for Injection 2000mg Pws Iv(Cyclophosphamide + Sodium Chloride) |
Category: | Mutagens, Antineoplastic Agents, Myeloablative Agonists, Antineoplastic Agents, Alkylating, Antirheumatic Agents, Immunosuppressive Agents |
CAS number: | 6055-19-2 |
Indication: | For management of malignant lymphomas, multiple myeloma,leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma and carcinoma of the breast |
---|---|
Pharmacology: |
Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - direct...
show more » |
Mechanism of Action: |
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the D...
show more » |
Absorption: | 90-100% |
Protein binding: | >60% |
Biotransformation: | hepatic |
Route of elimination: | It is eliminated primarily in the form of metabolites, but from 5% to 25% of the dose is excreted in urine as unchanged drug. |
Half Life: | 3-12 hours |
Toxicity: | infection, myelosuppression, and cardiac toxicity |
Affected organisms: | Humans and other mammals |
Food interaction: |
| ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Drug interaction: |
|