QuickView for Cyfip1 (gene)

Gene Symbol:

CYFIP1 Homo sapiens

Full name:

cytoplasmic FMR1 interacting protein 1

Synonyms:

P140SRA-1, SHYC, SRA-1, SRA1, cytoplasmic FMR1-interacting protein 1, cytoplasmic FMRP interacting protein 1, selective hybridizing clone, specifically Rac1-associated protein 1

Genomic Location:

Chr 15: 20444125-20555044

Description:

This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A...

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This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  AP1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  AP1FJ_Q2 ,  AP1_Q4 ,  CTTTGT_LEF1_Q2

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-381

Cytogenetic Map:

15q11.2

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