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QuickView for Cyr61 (gene)


Gene Symbol:
CYR61 Homo sapiens Homo sapiens
Full name:
cysteine rich angiogenic inducer 61
Synonyms:
CCN1, GIG1, IGFBP10, protein CYR61, CCN family member 1, IBP-10, IGF-binding protein 10, IGFBP-10, cysteine-rich heparin-binding protein 61, cysteine-rich, anigogenic inducer, 61, insulin-like growth factor-binding protein 10
Genomic Location:
Chr 1: 85819048-85821978
Description:
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 RTAAACA_FREAC2_01 HNF3ALPHA_Q6 OCT1_B TTANTCA_UNKNOWN TGGNNNNNNKCCAR_UNKNOWN TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D HFH3_01 OCT1_01 AML_Q6
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 1
1p22.3


Transcripts Names
NM_001554
Protein Names
Q9BZL7
O14934
O43775
Q6FI18
O00622



GO Molecular Function

protein-containing complex binding | signaling receptor binding | carbohydrate derivative binding | growth factor binding | extracellular matrix binding | insulin-like growth factor binding | anion binding | ion binding | integrin binding | heparin binding | cell adhesion molecule binding | protein binding | glycosaminoglycan binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | extracellular structure organization | cell motility | developmental process involved in reproduction | intussusceptive angiogenesis | positive regulation of apoptotic process | regulation of localization | morphogenesis of an epithelium | regulation of programmed cell death | regulation of osteoblast proliferation | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | reactive oxygen species metabolic process | positive regulation of sphingolipid biosynthetic process | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | cardiac atrium morphogenesis | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | positive regulation of cartilage development | regulation of cell motility | localization | heart morphogenesis | reproductive system development | positive regulation of protein kinase activity | negative regulation of apoptotic process | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cell differentiation | apoptotic process involved in heart morphogenesis | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | labyrinthine layer morphogenesis | regulation of metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | regulation of ceramide biosynthetic process | response to stimulus | chorio-allantoic fusion | vasculature development | wound healing, spreading of cells | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | regulation of cell proliferation | positive regulation of lipid biosynthetic process | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | programmed cell death | reproduction | atrioventricular valve morphogenesis | cardiovascular system development | positive regulation of proteolysis | positive regulation of lipase activity | extracellular matrix organization | positive regulation of BMP signaling pathway | positive regulation of RNA biosynthetic process | protein modification process | cartilage development | regulation of cell adhesion | embryo development | macromolecule modification | epiboly | embryonic placenta development | blood vessel development | regulation of nucleic acid-templated transcription | locomotion | apoptotic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | regulation of cartilage development | multicellular organism development | cell migration | regulation of peptidase activity | regulation of MAPK cascade | regulation of BMP signaling pathway | regulation of catalytic activity | regulation of phosphorylation | regulation of ossification | wound healing | regulation of gene expression | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of cell migration | regulation of cell-substrate adhesion | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cardiac atrium development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | morphogenesis of an epithelial sheet | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of cell migration | cell proliferation | labyrinthine layer development | regulation of cellular protein metabolic process | positive regulation of ossification | angiogenesis | cardiac septum morphogenesis | positive regulation of endopeptidase activity | regulation of phospholipase activity | labyrinthine layer blood vessel development | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | chondroblast differentiation | chordate embryonic development | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of osteoblast proliferation | heart development | apoptotic process involved in development | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of lipid biosynthetic process | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | positive regulation of molecular function | positive regulation of osteoblast differentiation | heart valve development | ventricular septum development | protein metabolic process | cardiac ventricle development | positive regulation of protein modification process | regulation of growth | tissue morphogenesis | regulation of kinase activity | response to wounding | positive regulation of ceramide biosynthetic process | regulation of intracellular signal transduction | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | positive regulation of cell death | cell adhesion | heart valve morphogenesis | organic substance metabolic process | connective tissue development | cell death | animal organ development | positive regulation of cell-substrate adhesion | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | cell-cell adhesion | atrioventricular valve development | positive regulation of phospholipase activity | atrial septum development | regulation of sphingolipid biosynthetic process | anatomical structure formation involved in morphogenesis | regulation of cell communication | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | regulation of endopeptidase activity | reproductive structure development | regulation of developmental process | developmental process | regulation of cell growth | cardiac septum development | cellular protein modification process | tube development | positive regulation of transcription, DNA-templated | atrial septum morphogenesis | positive regulation of nucleic acid-templated transcription | embryonic placenta morphogenesis | positive regulation of transcription by RNA polymerase II | cardiac chamber development | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | osteoblast differentiation | positive regulation of lipid metabolic process | apoptotic process involved in morphogenesis | skeletal system development | cellular metabolic process | placenta development | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | chemotaxis | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | post-translational protein modification | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | extracellular matrix | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular