QuickView for DAAM1;jsessionid=BE6AD10E377C147A77A850CBD071CAE2 (gene)

Gene Symbol:

DAAM1 Homo sapiens

Full name:

dishevelled associated activator of morphogenesis 1

Synonyms:

disheveled-associated activator of morphogenesis 1

Genomic Location:

Chr 14: 58725152-58906224

Description:

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A...

View Full Description

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  SMTTTTGT_UNKNOWN ,  HEN1_01 ,  YATTNATC_UNKNOWN ,  TAAYNRNNTCC_UNKNOWN ,  HNF1_C ,  ATCTTGC_MIR31 ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  SOX9_B1 ,  ACATTCC_MIR1_MIR206 ,  GGGYGTGNY_UNKNOWN ,  YYCATTCAWW_UNKNOWN ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  TGCGCANK_UNKNOWN ,  CCAWYNNGAAR_UNKNOWN ,  HNF3B_01 ,  ATF3_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  ATGTTAA_MIR302C ,  ACTGCCT_MIR34B ,  E47_01 ,  GCM_Q2 ,  OCT1_02 ,  AP2REP_01 ,  AAAYRNCTG_UNKNOWN ,  MYOGENIN_Q6 ,  GTCNYYATGR_UNKNOWN ,  HEN1_02 ,  ZIC2_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  YNGTTNNNATT_UNKNOWN ,  TGACATY_UNKNOWN ,  HNF1_Q6 ,  CEBPGAMMA_Q6 ,  GTTRYCATRR_UNKNOWN ,  HNF6_Q6 ,  GGGTGGRR_PAX4_03 ,  AAGCACA_MIR218 ,  LBP1_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-335 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b

Cytogenetic Map:

14q23.1

search → result