QuickView for DAO2 (gene)

Gene Symbol:

AOC2 Homo sapiens

Full name:

amine oxidase, copper containing 2

Synonyms:

DAO2, RAO, SSAO, retina-specific copper amine oxidase, amine oxidase, copper containing 2 (retina-specific), semicarbazide-sensitive amine oxidase

Genomic Location:

Chr 17: 38250135-38256250

Description:

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases ...

View Full Description

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTTGA_LEF1_Q2 ,  TTTNNANAGCYR_UNKNOWN ,  CTAWWWATA_RSRFC4_Q2 ,  TGACCTY_ERR1_Q2 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  CAGGTA_AREB6_01 ,  DR1_Q3 ,  CAGNWMCNNNGAC_UNKNOWN ,  NKX61_01 ,  RORA1_01 ,  TBP_01 ,  ER_Q6_02 ,  ER_Q6_01 ,  BRN2_01 ,  PPAR_DR1_Q2 ,  TGACATY_UNKNOWN ,  ERR1_Q2 ,  ER_Q6 ,  HNF1_Q6

View More

View Less

Cytogenetic Map:

17q21.31

search → result