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QuickView for DDT (gene)


Gene Symbol:
DDT Homo sapiens Homo sapiens
Full name:
D-dopachrome tautomerase
Synonyms:
DDCT, D-dopachrome decarboxylase, phenylpyruvate tautomerase II
Genomic Location:
Chr 22: 22643554-22652019
Description:
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 22
22q11.23


Transcripts Names
NM_001084392
NM_001355
Protein Names
Q13534
O60787
O00774
P30046
Q53Y51



GO Molecular Function

dopachrome isomerase activity | intramolecular oxidoreductase activity, transposing C=C bonds | phenylpyruvate tautomerase activity | isomerase activity | signaling receptor binding | cytokine receptor binding | lyase activity | carbon-carbon lyase activity | catalytic activity | intramolecular oxidoreductase activity | carboxy-lyase activity | D-dopachrome decarboxylase activity | protein binding

GO Biological Process

regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | negative regulation of immune system process | regulation of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of phosphate metabolic process | phenol-containing compound metabolic process | melanin metabolic process | cellular process | regulation of cell motility | regulation of chemotaxis | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of macrophage migration | negative regulation of cell motility | regulation of cellular process | regulation of metabolic process | negative regulation of chemotaxis | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | positive regulation of tumor necrosis factor production | positive regulation of protein metabolic process | negative regulation of leukocyte chemotaxis | cellular biosynthetic process | organic hydroxy compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | positive regulation of inflammatory response | regulation of phosphorylation | melanin biosynthetic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | pigment biosynthetic process | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | regulation of cellular component movement | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of tumor necrosis factor production | regulation of leukocyte migration | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of locomotion | positive regulation of protein modification process | regulation of intracellular signal transduction | metabolic process | organic substance metabolic process | pigment metabolic process | negative regulation of cellular component movement | positive regulation of ERK1 and ERK2 cascade | negative regulation of macrophage chemotaxis | regulation of phosphate metabolic process | positive regulation of cytokine production | positive regulation of MAPK cascade | regulation of cell communication | positive regulation of phosphorylation | regulation of cytokine production | negative regulation of leukocyte migration | regulation of macrophage chemotaxis | positive regulation of metabolic process | cellular metabolic process | regulation of inflammatory response | negative regulation of locomotion | positive regulation of signaling | regulation of signaling | regulation of phosphorus metabolic process

GO Cellular Component

cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular