QuickView for DDX3Y;jsessionid=409E800FC57E543BD115E74F6D15117A (gene)

Gene Symbol:

DDX3Y Homo sapiens

Full name:

DEAD-box helicase 3, Y-linked

Synonyms:

DBY, ATP-dependent RNA helicase DDX3Y, DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, DEAD box protein 3, Y-chromosomal, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, Y chromosome

Genomic Location:

Chr Y: 13526171-13541784

Description:

The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DD...

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The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  C. elegans ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Bos taurus ,  Rattus norvegicus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ACAACTT_MIR382 ,  TTTGCAC_MIR19A_MIR19B ,  SMTTTTGT_UNKNOWN ,  GTGTTGA_MIR505 ,  AAGCCAT_MIR135A_MIR135B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  ATGTCAC_MIR489 ,  GGGACCA_MIR133A_MIR133B ,  GTGACTT_MIR224 ,  GTACTGT_MIR101 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GTGTGAG_MIR342 ,  TTGGAGA_MIR5155P_MIR519E ,  CATGTAA_MIR496 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  ATTCTTT_MIR186 ,  GTTTGTT_MIR495 ,  ATGTTAA_MIR302C ,  AGGTGCA_MIR500 ,  AAAGACA_MIR511 ,  CAGCAGG_MIR370 ,  GTGCCTT_MIR506 ,  GGCACTT_MIR519E ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  AAACCAC_MIR140 ,  AACTTT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-433-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

Yq11.221

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