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QuickView for DGAT1 (gene)


Gene Symbol:
DGAT1 Homo sapiens Homo sapiens
Full name:
diacylglycerol O-acyltransferase 1
Synonyms:
ARAT, ARGP1, DGAT, DIAR7, diacylglycerol O-acyltransferase 1, ACAT related gene product 1, acyl coenzyme A:cholesterol acyltransferase related gene 1, acyl-CoA retinol O-fatty-acyltransferase, acyl-CoA:diacylglycerol acyltransferase, diacylglycerol O-acyltransferase homolog, diglyceride acyltransferase
Genomic Location:
Chr 8: 145510762-145521375
Description:
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Danio rerio Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Cytogenetic Map:
chr 8
8q24.3





GO Molecular Function

diacylglycerol O-acyltransferase activity | retinol O-fatty-acyltransferase activity | transferase activity, transferring acyl groups other than amino-acyl groups | catalytic activity | transferase activity, transferring acyl groups | 2-acylglycerol O-acyltransferase activity | acylglycerol O-acyltransferase activity | protein binding | transferase activity | O-acyltransferase activity

GO Biological Process

purine ribonucleotide metabolic process | very-low-density lipoprotein particle assembly | exocytosis | extracellular structure organization | neutrophil activation | retinol O-fatty-acyltransferase activity | sulfur compound metabolic process | establishment of localization | lipid storage | protein-lipid complex assembly | cellular process | secretion | leukocyte degranulation | localization | nucleotide metabolic process | anion homeostasis | triglyceride metabolic process | ribose phosphate metabolic process | macromolecule localization | long-chain fatty-acyl-CoA metabolic process | ribonucleotide metabolic process | leukocyte activation | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | response to stimulus | purine nucleotide metabolic process | neutrophil degranulation | leukocyte activation involved in immune response | alcohol metabolic process | regulation of plasma lipoprotein particle levels | secretion by cell | retinol metabolic process | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular component assembly | cellular biosynthetic process | organic hydroxy compound metabolic process | retinoid metabolic process | nitrogen compound metabolic process | phosphorus metabolic process | acyl-CoA metabolic process | leukocyte mediated immunity | lipid metabolic process | regulation of hormone levels | organophosphate metabolic process | small molecule metabolic process | cellular amide metabolic process | vesicle-mediated transport | nucleobase-containing small molecule metabolic process | biosynthetic process | plasma lipoprotein particle assembly | regulated exocytosis | lipid biosynthetic process | phosphate-containing compound metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | homeostatic process | glycerolipid metabolic process | protein-containing complex assembly | diacylglycerol metabolic process | neutral lipid metabolic process | fatty acid homeostasis | metabolic process | lipid localization | chemical homeostasis | acylglycerol acyl-chain remodeling | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | diterpenoid metabolic process | ion homeostasis | cell activation | hormone metabolic process | isoprenoid metabolic process | carbohydrate derivative metabolic process | neutrophil mediated immunity | heterocycle metabolic process | immune system process | cellular metabolic process | triglyceride biosynthetic process | acylglycerol metabolic process | lipid homeostasis | multicellular organismal process

GO Cellular Component

secretory granule | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | secretory granule membrane | nuclear outer membrane-endoplasmic reticulum membrane network | secretory vesicle | endomembrane system | endoplasmic reticulum membrane | plasma membrane | vesicle | specific granule | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | intracellular vesicle | intracellular | specific granule membrane | membrane | cytoplasmic vesicle membrane