QuickView for DGKA (gene)
- Gene Symbol:
- DGKA
Homo sapiens - Full name:
- diacylglycerol kinase alpha
- Synonyms:
- DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha, 80 kDa diacylglycerol kinase, DAG kinase alpha, diacylglycerol kinase, alpha 80kDa, diglyceride kinase alpha
- Genomic Location:
- Chr 12: 54611213-54634074
- Description:
-
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidi...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , TGANTCA_AP1_C , ETS_Q4 , TTANTCA_UNKNOWN , RYTTCCTG_ETS2_B , P53_DECAMER_Q2 , CIZ_01 , TEL2_Q6 , IRF1_Q6 , E2A_Q2
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.2
GO Molecular Function
cation binding | ribonucleotide binding | lipid binding | nucleotide binding | carbohydrate derivative binding | phospholipid binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | diacylglycerol kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | transferase activity | calcium ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | NAD+ kinase activity | small molecule binding
GO Biological Process
intracellular signal transduction | phospholipid metabolic process | cellular process | hemostasis | regulation of cellular process | cellular lipid metabolic process | response to stimulus | response to stress | G-protein coupled receptor signaling pathway | cellular biosynthetic process | blood coagulation | phosphatidic acid metabolic process | phosphorus metabolic process | lipid metabolic process | wound healing | platelet activation | organophosphate metabolic process | phospholipid biosynthetic process | biosynthetic process | phosphorylation | lipid biosynthetic process | phosphate-containing compound metabolic process | lipid phosphorylation | cell communication | lipid modification | protein kinase C-activating G-protein coupled receptor signaling pathway | glycerolipid metabolic process | coagulation | diacylglycerol metabolic process | neutral lipid metabolic process | glycerophospholipid biosynthetic process | response to wounding | diacylglycerol kinase activity | metabolic process | regulation of body fluid levels | organic substance metabolic process | cell activation | signaling | glycerophospholipid metabolic process | kinase activity | phosphatidic acid biosynthetic process | cellular metabolic process | acylglycerol metabolic process | NAD+ kinase activity | signal transduction | multicellular organismal process
GO Cellular Component
cell | cytoplasm | plasma membrane | cell periphery | cytosol | intracellular | membrane
