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QuickView for DNMT (gene)


Gene Symbol:
DNMT1 Homo sapiens Homo sapiens
Full name:
DNA methyltransferase 1
Synonyms:
ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, DNA (cytosine-5-)-methyltransferase 1, DNA MTase HsaI, DNA methyltransferase HsaI
Genomic Location:
Chr 19: 10105022-10166811
Description:
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant me...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19p13.2





GO Molecular Function

sequence-specific DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | nucleotide binding | catalytic activity | chromatin binding | DNA binding | promoter-specific chromatin binding | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | DNA-binding transcription factor activity | DNA-methyltransferase activity | transferase activity | transition metal ion binding | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | methyl-CpG binding | metal ion binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | positive regulation of smooth muscle cell proliferation | negative regulation of smooth muscle cell apoptotic process | positive regulation of cellular component organization | intracellular signal transduction | regulation of programmed cell death | DNA modification | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | regulation of phenotypic switching | regulation of organelle organization | positive regulation of vascular smooth muscle cell proliferation | cellular process | regulation of gene expression, epigenetic | chromatin organization | DNA methylation involved in embryo development | regulation of methylation-dependent chromatin silencing | regulation of histone H3-K9 methylation | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of apoptotic process | negative regulation of phenotypic switching | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of histone methylation | regulation of cellular process | regulation of apoptotic process | gene silencing | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | small GTPase mediated signal transduction | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | positive regulation of chromatin silencing | regulation of histone methylation | regulation of vasculature development | response to stimulus | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | embryo development | macromolecule modification | regulation of nucleic acid-templated transcription | response to nitrogen compound | nitrogen compound metabolic process | positive regulation of organelle organization | multicellular organism development | response to amino acid | positive regulation of chromosome organization | regulation of gene expression | negative regulation of histone H3-K9 methylation | methylation | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of smooth muscle cell differentiation | positive regulation of methylation-dependent chromatin silencing | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | DNA methylation | regulation of smooth muscle cell apoptotic process | DNA methylation on cytosine | negative regulation of smooth muscle cell differentiation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular response to amino acid stimulus | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | regulation of histone H3-K4 methylation | DNA methylation on cytosine within a CG sequence | positive regulation of cell proliferation | negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching | regulation of RNA metabolic process | DNA-binding transcription factor activity | positive regulation of protein modification process | response to organic substance | DNA-methyltransferase activity | C-5 methylation of cytosine | DNA metabolic process | anatomical structure development | metabolic process | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of muscle cell apoptotic process | negative regulation of vascular associated smooth muscle cell apoptotic process | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | regulation of chromosome organization | negative regulation of vascular smooth muscle cell differentiation | transcription, DNA-templated | maintenance of DNA methylation | negative regulation of protein metabolic process | negative regulation of chromosome organization | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of developmental process | DNA (cytosine-5-)-methyltransferase activity | methyltransferase activity | positive regulation of DNA metabolic process | developmental process | organelle organization | regulation of muscle cell differentiation | negative regulation of transcription by RNA polymerase II | negative regulation of vasculature development | Ras protein signal transduction | response to organonitrogen compound | heterocycle metabolic process | negative regulation of muscle cell differentiation | positive regulation of metabolic process | chromosome organization | positive regulation of histone methylation | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of cell death | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | nuclear lumen | replication fork | intracellular organelle | nucleoplasm | chromatin | pericentric heterochromatin | membrane-bounded organelle | heterochromatin | nucleus | organelle | membrane-enclosed lumen | intracellular