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QuickView for DOCK8 (gene)


Gene Symbol:
DOCK8 Homo sapiens Homo sapiens
Full name:
dedicator of cytokinesis 8
Synonyms:
HEL-205, MRD2, ZIR8, dedicator of cytokinesis protein 8, 1200017A24Rik, epididymis luminal protein 205
Genomic Location:
Chr 9: 263048-455255
Description:
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding dif...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9p24.3





GO Molecular Function

guanyl-nucleotide exchange factor activity | GTPase binding | enzyme binding | molecular function regulator | protein binding

GO Biological Process

positive regulation of locomotion | guanyl-nucleotide exchange factor activity | response to cytokine | cell motility | intracellular signal transduction | regulation of localization | regulation of programmed cell death | regulation of immune system process | negative regulation of cellular process | positive regulation of lymphocyte activation | positive regulation of cell adhesion | positive regulation of cellular component movement | positive regulation of GTPase activity | cellular process | regulation of cell motility | localization | hemostasis | negative regulation of apoptotic process | positive regulation of catalytic activity | cell recognition | regulation of lymphocyte apoptotic process | regulation of cellular process | leukocyte activation | regulation of apoptotic process | small GTPase mediated signal transduction | regulation of establishment of cell polarity | T cell activation | response to stimulus | negative regulation of T cell apoptotic process | positive regulation of immune system process | mononuclear cell proliferation | response to stress | positive regulation of T cell migration | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | dendritic cell migration | regulation of cell adhesion | molecular function regulator | regulation of establishment or maintenance of cell polarity | leukocyte migration | blood coagulation | locomotion | cellular response to chemokine | cell migration | regulation of catalytic activity | positive regulation of lymphocyte migration | wound healing | regulation of T cell activation | cell-cell recognition | regulation of lymphocyte activation | negative regulation of lymphocyte apoptotic process | regulation of cell migration | regulation of cellular component movement | positive regulation of hydrolase activity | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | regulation of GTPase activity | regulation of leukocyte migration | cell communication | regulation of T cell apoptotic process | regulation of T cell migration | regulation of locomotion | coagulation | lymphocyte activation | positive regulation of molecular function | memory T cell proliferation | response to organic substance | response to wounding | positive regulation of establishment of T cell polarity | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of programmed cell death | T cell proliferation | regulation of cell activation | positive regulation of leukocyte migration | cell activation | lymphocyte proliferation | signaling | negative regulation of leukocyte apoptotic process | immunological synapse formation | regulation of cell-cell adhesion | immune system process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | regulation of lymphocyte migration | regulation of establishment of T cell polarity | signal transduction | multicellular organismal process

GO Cellular Component

cell projection membrane | cell | lamellipodium | cytoplasm | leading edge membrane | cell projection | plasma membrane | cell leading edge | cell periphery | cytosol | intracellular | membrane | lamellipodium membrane