QuickView for DROSHA (gene)
- Gene Symbol:
- DROSHA
Homo sapiens - Full name:
- drosha ribonuclease III
- Synonyms:
- ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN, ribonuclease 3, RNase III, drosha, double-stranded RNA-specific endoribonuclease, nuclear RNase III Drosha, p241, putative protein p241 which interacts with transcription factor Sp1, putative ribonuclease III, ribonuclease type III, nuclear
- Genomic Location:
- Chr 5: 31436358-31568039
- Description:
-
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (p...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5p13.3
GO Molecular Function
nuclease activity | cation binding | endoribonuclease activity, producing 5'-phosphomonoesters | enzyme binding | nucleic acid binding | lipid binding | DEAD/H-box RNA helicase binding | hydrolase activity | carbohydrate derivative binding | ribonuclease activity | catalytic activity | hydrolase activity, acting on ester bonds | identical protein binding | primary miRNA binding | ion binding | organic cyclic compound binding | protein binding | endoribonuclease activity | protein homodimerization activity | protein dimerization activity | lipopolysaccharide binding | endonuclease activity | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | SMAD binding | metal ion binding | ribonuclease III activity | heterocyclic compound binding | double-stranded RNA-specific ribonuclease activity | R-SMAD binding | RNA binding | double-stranded RNA binding
GO Biological Process
RNA metabolic process | gene silencing by RNA | RNA processing | nuclease activity | defense response to other organism | regulation of immune system process | regulation of T cell differentiation | defense response | production of small RNA involved in gene silencing by RNA | defense response to Gram-negative bacterium | cellular process | regulation of gene expression, epigenetic | organic substance catabolic process | dsRNA fragmentation | endoribonuclease activity, producing 5'-phosphomonoesters | ribosome biogenesis | regulation of cell differentiation | regulation of cellular process | gene silencing | regulation of metabolic process | catabolic process | production of miRNAs involved in gene silencing by miRNA | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | regulation of regulatory T cell differentiation | response to stress | posttranscriptional regulation of gene expression | ncRNA processing | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | cellular response to organic cyclic compound | negative regulation of metabolic process | ribonuclease activity | nucleobase-containing compound catabolic process | regulation of lymphocyte differentiation | primary miRNA processing | response to nitrogen compound | response to external biotic stimulus | RNA interference | nitrogen compound metabolic process | response to dsRNA | regulation of miRNA metabolic process | regulation of T cell activation | regulation of gene expression | gene silencing by miRNA | RNA catabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | rRNA metabolic process | rRNA catabolic process | response to bacterium | posttranscriptional gene silencing | regulation of cellular metabolic process | aromatic compound catabolic process | cellular response to dsRNA | defense response to bacterium | regulation of RNA metabolic process | endoribonuclease activity | posttranscriptional gene silencing by RNA | response to organic substance | regulation of hemopoiesis | cellular macromolecule catabolic process | metabolic process | RNA phosphodiester bond hydrolysis, endonucleolytic | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | gene expression | regulation of cell activation | endonuclease activity | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | defense response to Gram-positive bacterium | pre-miRNA processing | response to organic cyclic compound | response to biotic stimulus | regulation of developmental process | ncRNA metabolic process | heterocycle metabolic process | positive regulation of metabolic process | ribonuclease III activity | ribonucleoprotein complex biogenesis | cellular metabolic process | double-stranded RNA-specific ribonuclease activity | production of siRNA involved in RNA interference | cellular response to organic substance | regulation of inflammatory response | miRNA metabolic process | response to other organism | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | synapse | catalytic complex | cell | nuclear lumen | nucleolus | intracellular organelle | protein-containing complex | postsynapse | nucleoplasm | postsynaptic density | asymmetric synapse | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | membrane-enclosed lumen | microprocessor complex | intracellular
