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QuickView for Dcc (gene)


Gene Symbol:
DCC Homo sapiens Homo sapiens
Full name:
DCC netrin 1 receptor
Synonyms:
CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1, netrin receptor DCC, colorectal cancer suppressor, deleted in colorectal carcinoma, immunoglobulin superfamily DCC subclass member 1, putative colorectal tumor suppressor, tumor suppressor protein DCC
Genomic Location:
Chr 18: 48120569-49311780
Description:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 18
18q21.2





GO Molecular Function

transmembrane signaling receptor activity | signaling receptor activity | protein binding | netrin receptor activity

GO Biological Process

cell morphogenesis | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | negative regulation of netrin-activated signaling pathway | regulation of cell development | neuron migration | negative regulation of cellular process | cell differentiation | negative regulation of dendrite development | nervous system development | cell part morphogenesis | neurogenesis | generation of neurons | regulation of neuron death | cellular process | negative regulation of axonogenesis | central nervous system neuron axonogenesis | localization | cell projection morphogenesis | extrinsic apoptotic signaling pathway | negative regulation of signaling | neuron development | negative regulation of developmental growth | central nervous system neuron differentiation | axon guidance | regulation of neuron projection development | regulation of cell differentiation | regulation of cellular process | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | response to stimulus | cell morphogenesis involved in neuron differentiation | negative regulation of collateral sprouting | neuron projection guidance | negative regulation of neuron projection development | programmed cell death | regulation of cellular component size | locomotion | central nervous system neuron development | apoptotic process | system development | regulation of signal transduction | negative regulation of growth | central nervous system projection neuron axonogenesis | multicellular organism development | cell migration | regulation of axonogenesis | anterior/posterior axon guidance | regulation of neuron differentiation | axon development | dorsal/ventral axon guidance | axonogenesis | cell morphogenesis involved in differentiation | spinal cord ventral commissure morphogenesis | cell communication | negative regulation of cell growth | apoptotic signaling pathway | neuron differentiation | regulation of cell morphogenesis involved in differentiation | regulation of growth | negative regulation of cell projection organization | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | neuron projection development | cell death | animal organ development | negative regulation of neuron differentiation | regulation of dendrite development | regulation of collateral sprouting | regulation of cell communication | negative regulation of signal transduction | signaling | cell development | regulation of developmental growth | extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell size | anatomical structure morphogenesis | regulation of nervous system development | regulation of developmental process | developmental process | regulation of cell growth | netrin-activated signaling pathway | netrin receptor activity | central nervous system development | spinal cord development | regulation of cell projection organization | regulation of cell death | negative regulation of cell development | chemotaxis | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

integral component of membrane | neuron projection | cell | intrinsic component of membrane | cytoplasm | cell projection | plasma membrane | cell periphery | axon | cytosol | intracellular | membrane