QuickView for Ddit3 (gene)
- Gene Symbol:
- DDIT3
Homo sapiens - Full name:
- DNA damage inducible transcript 3
- Synonyms:
- C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3 protein, C/EBP zeta, CCAAT/enhancer-binding protein homologous protein, c/EBP-homologous protein 10, growth arrest and DNA damage-inducible protein GADD153
- Genomic Location:
- Chr 12: 56196638-56200567
- Description:
-
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and e...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12q13.3
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | leucine zipper domain binding | LRR domain binding | cAMP response element binding protein binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to endoplasmic reticulum stress | intracellular signal transduction | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | proteolysis | protein localization to mitochondrion | cytosolic calcium ion transport | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | positive regulation of intrinsic apoptotic signaling pathway | negative regulation of fat cell differentiation | ATF6-mediated unfolded protein response | cellular chemical homeostasis | negative regulation of determination of dorsal identity | PERK-mediated unfolded protein response | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | localization | cellular homeostasis | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | metal ion transport | establishment of protein localization to mitochondrion | negative regulation of nucleic acid-templated transcription | macromolecule localization | endoplasmic reticulum unfolded protein response | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | cellular response to nitrosative stress | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | intrinsic apoptotic signaling pathway | positive regulation of interleukin-8 production | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | negative regulation of CREB transcription factor activity | regulation of cytosolic calcium ion concentration | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular component organization | cellular response to topologically incorrect protein | calcium ion homeostasis | calcium ion transport into cytosol | response to stimulus | vasculature development | response to stress | cell redox homeostasis | regulation of response to endoplasmic reticulum stress | cellular nitrogen compound biosynthetic process | response to starvation | programmed cell death | regulation of transcription regulatory region DNA binding | cellular protein catabolic process | cellular localization | divalent metal ion transport | cardiovascular system development | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | regulation of DNA binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | mRNA metabolic process | cellular biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | blood vessel development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | calcium ion transmembrane transport | cellular response to DNA damage stimulus | protein complex oligomerization | negative regulation of cold-induced thermogenesis | ER-nucleus signaling pathway | regulation of intrinsic apoptotic signaling pathway | ion transmembrane transport | mRNA transcription by RNA polymerase II | regulation of transcription involved in anterior/posterior axis specification | response to nitrosative stress | regulation of gene expression | cellular response to stress | cell cycle | protein catabolic process | positive regulation of cellular metabolic process | cellular ion homeostasis | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | negative regulation of DNA binding | transcription corepressor activity | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of binding | negative regulation of myoblast differentiation | biosynthetic process | negative regulation of protein kinase B signaling | negative regulation of sequestering of calcium ion | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | negative regulation of transcription regulatory region DNA binding | positive regulation of neuron death | regulation of apoptotic signaling pathway | cation homeostasis | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | anterior/posterior axis specification | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | mRNA transcription | regulation of RNA metabolic process | apoptotic signaling pathway | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | proteasome-mediated ubiquitin-dependent protein catabolic process | ER overload response | positive regulation of molecular function | release of sequestered calcium ion into cytosol | cation transmembrane transport | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regionalization | axis specification | response to organic substance | cell cycle arrest | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | positive regulation of neuron apoptotic process | establishment of protein localization to organelle | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | developmental maturation | negative regulation of transcription, DNA-templated | regulation of myoblast differentiation | cellular protein localization | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | calcium ion transport | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of sequestering of calcium ion | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of programmed cell death | ion homeostasis | regulation of Wnt signaling pathway | inorganic cation transmembrane transport | establishment of protein localization | transcription, DNA-templated | blood vessel maturation | positive regulation of cytokine production | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | response to unfolded protein | regulation of cytokine production | cation transport | cellular macromolecule localization | cellular macromolecule biosynthetic process | response to biotic stimulus | regulation of developmental process | regulation of RNA polymerase II regulatory region sequence-specific DNA binding | developmental process | negative regulation of canonical Wnt signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | ion transport | cellular metabolic process | cellular response to organic substance | intrinsic apoptotic signaling pathway in response to nitrosative stress | regulation of cell death | modification-dependent protein catabolic process | circulatory system development | divalent inorganic cation homeostasis | negative regulation of cell differentiation | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | late endosome | RNA polymerase II transcription factor complex | cytoplasmic vesicle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | CHOP-ATF4 complex | protein-containing complex | endomembrane system | protein-DNA complex | nucleoplasm | CHOP-ATF3 complex | vesicle | endosome | membrane-bounded organelle | nucleus | organelle | CHOP-C/EBP complex | membrane-enclosed lumen | transcription factor AP-1 complex | cytosol | intracellular vesicle | intracellular
