QuickView for Deleted in Oral Cancer 1 (gene)

Gene Symbol:

CDK2AP1 Homo sapiens

Full name:

cyclin dependent kinase 2 associated protein 1

Synonyms:

DOC1, DORC1, ST19, doc-1, p12DOC-1, cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Deleted in oral cancer-1, deleted in oral cancer 1, putative oral cancer suppressor

Genomic Location:

Chr 12: 122311491-122322640

Description:

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, whic...

View Full Description

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SMTTTTGT_UNKNOWN ,  TTTGCAG_MIR518A2 ,  TTANTCA_UNKNOWN ,  TGGNNNNNNKCCAR_UNKNOWN ,  ZF5_01 ,  AAANWWTGC_UNKNOWN ,  LYF1_01 ,  TACTTGA_MIR26A_MIR26B ,  E2F1_Q4 ,  CTTTGTA_MIR524 ,  CAGGTA_AREB6_01 ,  PXR_Q2 ,  EGR_Q6 ,  CDPCR3_01 ,  HAND1E47_01 ,  ARGGGTTAA_UNKNOWN ,  AACTTT_UNKNOWN ,  GGGTGGRR_PAX4_03

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-488

Cytogenetic Map:

12q24.31

search → result