Name: | demecarium bromide |
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PubChem Compound ID: | 5965 |
Molecular formula: | C32H52Br2N4O4 |
Molecular weight: | 716.588 g/mol |
Synonyms: |
Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate); Humorsol (TN); BC 48; Bromuro de demecario [INN-Spanish]; Visumiotic; Tonilen; Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate) (2:1); 56-94-0; Demecarii bromidum [INN-Latin]; N,N'-Bis(3-trimethylammoniumphenoxycarbonyl)-N,N'-dimethyldecamethylenediamine dibromide.
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Name: | demecarium bromide |
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Name (isomeric): | DB00944 |
Drug Type: | small molecule |
Synonyms: |
Demecarium bromide
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Category: | Miotics, Cholinergic Agents |
CAS number: | 56-94-0 |
Indication: | For the topical treatment of chronic open-angle glaucoma. |
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Pharmacology: |
Demecarium is a long-acting cholinesterase inhibitor and potent miotic. Because of its toxicity, it should be reserved for use in patients with open-angle glaucoma or other chronic glaucomas not satisfactorily controlled with the short-acting miotics and other agents. Application of demecarium to the eye produces intense miosis and ciliary muscle c...
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Mechanism of Action: |
Demecarium is an indirect-acting parasympathomimetic agent, also known as a cholinesterase inhibitor and anticholinesterase. Cholinesterase inhibitors prolong the effect of acetylcholine, which is released at the neuroeffector junction of parasympathetic postganglion nerves, by inactivating the cholinesterases that break it down. Demecarium inactiv...
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Toxicity: | The oral LD50 is 2.96 mg/kg in the mouse. Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea, urinary incontinence, salivation, sweating, difficulty in breathing, bradycardia, or cardiac irregularities. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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