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QuickView for Deserpidine (compound)

Name: deserpidine
PubChem Compound ID: 11757905
Molecular formula: C32H38N2O8
Molecular weight: 578.653 g/mol
Name: deserpidine
Name (isomeric): DB01089
Drug Type: small molecule
Deserpidinum [INN-Latin]; Deserpidin; Desepridine; Deserpidina [INN-Spanish]; Deserpine; Deresperine; Desmethoxyreserpine
Brand: Recanescine, Enduronyl, beta-Escin, Aescin, Raunormin, Reserpidine, Tranquinil, Canescin, Harmonyl, Canescine, Raunormine, Recanescin, Raunorine
Category: Antihypertensive Agents
CAS number: 131-01-1
Indication: For the treatment of hypertension.
Pharmacology: Deserpidine, an alkaloid of Rauwolfia canescens, is used as an antihypertensive. Rauwolfia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure.
Mechanism of Action:
Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecho...
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Toxicity: Symptoms of overdose include dizziness or drowsiness (severe), flushing of skin, pinpoint pupils of eyes and slowed pulse.
Affected organisms: Humans and other mammals
Drug interaction:
PseudoephedrineIncreased arterial pressure
PhenylpropanolamineIncreased arterial pressure
TerbutalineIncreased arterial pressure
FenoterolIncreased arterial pressure
OrciprenalineIncreased arterial pressure
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