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QuickView for Dexbrompheniramine (compound)

Summary
General Info

PubChem

PubChem Compound 16960

PubChem Compound 16960

Name:	dexbrompheniramine
PubChem Compound ID:	16960
Molecular formula:	C₁₆H₁₉BrN₂
Molecular weight:	319.24 g/mol
Synonyms:	( )-N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin; ( )-(3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin; Dexbrompheniramine; Brompheniramine d-; Dexbromfeniramina [INN-Spanish]; EINECS 205-053-5; 132-21-8; Dexbrompheniramine Brompheniramine; Dexbrompheniraminum [INN-Latin]

DrugBank

Identification

Name:	dexbrompheniramine
Name (isomeric):	DB00405
Drug Type:	small molecule
Synonyms:	D-Brompheniramine; Parabromdylamine; Parabromodylamine
Brand:	Ilvin
Brand name mixture:	Drixoral Cold & Sinus(Dexbrompheniramine Maleate + Pseudoephedrine Sulfate), Drixtab Tab(Dexbrompheniramine Maleate + Pseudoephedrine Sulfate), Drixoral Syrup(Dexbrompheniramine Maleate + Pseudoephedrine Sulfate), Drixoral Day/Night - Srt/Tabs(Dexbrompheniramine Maleate + Pseudoephedrine Sulfate)
Category:	Antihistamines
CAS number:	132-21-8

Pharmacology

Indication:	For treatment and relief of symptoms of allergies, hay fever, and colds
Pharmacology:	In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once rel... show more » In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H₁-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dexbrompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. show less «
Mechanism of Action:	Dexbrompheniramine competitively binds to the histamine H₁-receptor. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symp... show more » Dexbrompheniramine competitively binds to the histamine H₁-receptor. It competes with histamine for the normal H₁-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. show less «
Absorption:	Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
Biotransformation:	Hepatic (cytochrome P-450 system), some renal.
Half Life:	25 hours
Toxicity:	Signs of an overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Triprolidine	Triprolidine and Dexbrompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Donepezil	Possible antagonism of action
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Dexbrompheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide	Trimethobenzamide and Dexbrompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Galantamine	Possible antagonism of action

Targets

Histamine H1 receptor