Name: | Dichlorphenamide |
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PubChem Compound ID: | 3038 |
Description: | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. |
Molecular formula: | C6H6Cl2N2O4S2 |
Molecular weight: | 305.16 g/mol |
Synonyms: |
Dichlorphenamide (USP); Diclofenamida [INN-Spanish]; Diclofenamide (JP15); CAS-120-97-8; m-Benzenedisulfonamide, 4,5-dichloro-; 4,5-Dichloro-m-benzenedisulfonamide; 4-11-00-00555 (Beilstein Handbook Reference); Dichlorophenamide; Diclofenamidum [INN-Latin]; 3,4-Dichloro-5-sulfamylbenzenesulfonamide.
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Name: | Dichlorphenamide |
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Name (isomeric): | DB01144 |
Drug Type: | small molecule |
Description: | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. |
Synonyms: |
Diclofenamidum [INN-Latin]; Dichlorophenamide; Diclofenamida [INN-Spanish]; 4,5-Dicholorobenzene-1,3-disulfonamide; Dichlorphenamid; Dichlofenamide; Diclofenamide
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Brand: | Glaucol, Oratrol, Antidrasi, Dasanide, Daranide |
Category: | Carbonic Anhydrase Inhibitors, Antiglaucomic Agents, Ophthalmics |
CAS number: | 120-97-8 |
Indication: | For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure |
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Pharmacology: |
Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially ...
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Mechanism of Action: |
Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and d...
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Protein binding: | 55% |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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