QuickView for Dmrt1 (gene)

Gene Symbol:

DMRT1 Homo sapiens

Full name:

doublesex and mab-3 related transcription factor 1

Synonyms:

CT154, DMT1, doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis 1, DM domain expressed in testis protein 1

Genomic Location:

Chr 9: 831690-959090

Description:

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexu...

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This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAGCCAT_MIR135A_MIR135B ,  E2F1_Q4_01 ,  E2F_Q6_01 ,  RGAANNTTC_HSF1_01 ,  HSF1_01 ,  TGCCTTA_MIR124A ,  GTTTGTT_MIR495 ,  HSF2_01 ,  E2F_Q4_01 ,  GTGCCTT_MIR506 ,  AAAYRNCTG_UNKNOWN ,  E2F_Q3_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

9p24.3

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