QuickView for Dnmt3a (gene)

Gene Symbol:

DNMT3A Homo sapiens

Full name:

DNA methyltransferase 3 alpha

Synonyms:

DNMT3A2, M.HsaIIIA, TBRS, DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA MTase HsaIIIA, DNA cytosine methyltransferase 3A2

Genomic Location:

Chr 2: 25309349-25418963

Description:

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance meth...

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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  SP1_01 ,  MAZR_01 ,  USF_Q6 ,  ARNT_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AREB6_02 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  CTACTGT_MIR199A ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  VDR_Q6 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTACTGT_MIR101 ,  COUP_01 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  DR1_Q3 ,  AP2_Q6_01 ,  SP3_Q3 ,  GTCTTCC_MIR7 ,  RRAGTTGT_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  AREB6_01 ,  TGCTGAY_UNKNOWN ,  USF_C ,  USF_01 ,  CAGCAGG_MIR370 ,  PTF1BETA_Q6 ,  AGGGCCA_MIR328 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  NMYC_01 ,  AP2_Q6 ,  USF_Q6_01 ,  AP2REP_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  RGAGGAARY_PU1_Q6 ,  CTGCAGY_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  CTGTTAC_MIR194 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  MZF1_02 ,  PPAR_DR1_Q2 ,  ER_Q6 ,  USF_02 ,  TCATCTC_MIR143 ,  CCACACA_MIR147 ,  SP1_Q2_01 ,  TCCAGAG_MIR518C ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-410

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miRNA binding sites
(Source: miRecords):

hsa-miR-29a Targeted Genes ,  hsa-miR-29b Targeted Genes ,  hsa-miR-29c Targeted Genes

Cytogenetic Map:

2p23.3

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