QuickView for Dock8 (gene)

Gene Symbol:

DOCK8 Homo sapiens

Full name:

dedicator of cytokinesis 8

Synonyms:

HEL-205, MRD2, ZIR8, dedicator of cytokinesis protein 8, 1200017A24Rik, epididymis luminal protein 205

Genomic Location:

Chr 9: 263048-455255

Description:

This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding dif...

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This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTATTTTNR_MEF2_02 ,  GCCATNTTG_YY1_Q6 ,  GATA6_01 ,  MGGAAGTG_GABP_B ,  CEBP_Q3

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-410

Cytogenetic Map:

9p24.3

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