QuickView for Drs2 (gene)
- Gene Symbol:
- DRS2
Saccharomyces cerevisiae - Full name:
- Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
- Synonyms:
- DRS2, FUN38, SWA3, YAL026C
- Genomic Location:
- Chr I: 95631-99698
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cation binding | magnesium ion binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | phospholipid transporter activity | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | lipid transporter activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | phospholipid-translocating ATPase activity
GO Biological Process
lipid transport | establishment of localization | membrane organization | intracellular transport | cellular process | localization | protein transport | response to pheromone | cellular response to pheromone | anion transport | macromolecule localization | ribosome biogenesis | regulation of membrane lipid distribution | establishment of localization in cell | regulation of cellular process | cellular component organization | response to stimulus | endosomal transport | intracellular protein transport | cellular localization | cellular component assembly | response to pheromone triggering conjugation with cellular fusion | organelle assembly | phospholipid transporter activity | post-Golgi vesicle-mediated transport | organic substance transport | peptide transport | vesicle-mediated transport | ribosome assembly | organic anion transport | ribosomal small subunit assembly | cellular protein-containing complex assembly | endocytic recycling | Golgi vesicle transport | positive regulation of conjugation with cellular fusion | phospholipid transport | protein-containing complex assembly | response to organic substance | import into cell | lipid localization | cellular protein localization | amide transport | endocytosis | ribonucleoprotein complex assembly | establishment of protein localization | protein localization | cellular macromolecule localization | organelle organization | phospholipid translocation | ribosomal small subunit biogenesis | lipid transporter activity | ribonucleoprotein complex biogenesis | ion transport | cellular response to organic substance | phospholipid-translocating ATPase activity
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | protein-containing complex | Cdc50p-Drs2p complex | endomembrane system | plasma membrane | Golgi membrane | membrane-bounded organelle | organelle | cell periphery | trans-Golgi network | intracellular | membrane
