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QuickView for Dyphylline (compound)
PubChem
| Name: | Dyphylline |
|---|---|
| PubChem Compound ID: | 3182 |
| Description: | A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. |
| Molecular formula: | C10H14N4O4 |
| Molecular weight: | 254.243 g/mol |
| Synonyms: |
(1,2-Dihydroxy-3-propyl)thiophyllin; Neophyllin M; 7-(2, 3-Dihydroxypropyl)theophylline; Glyphyllinum; Neophylline; Neutraphyllin; Neostenovasan; Propyphyllin; Hyphylline; Diphylline.
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DrugBank
Identification
| Name: | Dyphylline |
|---|---|
| Name (isomeric): | DB00651 |
| Drug Type: | small molecule |
| Description: | A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. |
| Synonyms: |
DT; Diprofillin; Diprofilline; Diprophylline; Diprophyllin; Dihydroxypropyl Theopylin; Dipropylline; Dihydroxypropyl Theophylline
|
| Brand: | Propyphyllin, Neophyllin, Asthmolysin, Teofen, Neotilina, Tefilan, Circain, Thefylan, Droxine, Dyflex, Glyfyllin, Hidroxiteofillina, Iphyllin, Aristophyllin, Neutroxantina, Purifilin, Neophylline, Hiphyllin, Synthophylline, Neufil, Solufilin, Neutraphyllin, Soluphyllin, Glyphylline, Silbephylline, Corphyllin, Neutrafil, Neo-Vasophylline, Cor-Theophylline, Neostenovasan, Solufyllin, Neophyl, Hyphylline, Silbephyllin, Protheophylline, Glyphyllin, Astrophyllin, Coronarin, Neutraphylline, Afi-Phyllin, Liactemin, Theal, Coronal, Neutrafillina |
| Category: | Vasodilator Agents, Respiratory Smooth Muscle Relaxants, Phosphodiesterase Inhibitors, Bronchodilator Agents |
| CAS number: | 479-18-5 |
Pharmacology
| Indication: | For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. |
|---|---|
| Pharmacology: |
Dyphylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Dyphylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilat...
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| Mechanism of Action: | The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors. |
| Protein binding: | 84% |
| Biotransformation: | Hepatic |
| Route of elimination: | Dyphylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged. |
| Half Life: | 2 hours (range 1.8 - 2.1 hours) |
| Toxicity: | LD50=1954 mg/kg (orally in mice) |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
