QuickView for E2F1 (gene)

Gene Symbol:

E2F1 Homo sapiens

Full name:

E2F transcription factor 1

Synonyms:

E2F-1, RBAP1, RBBP3, RBP3, transcription factor E2F1, PBR3, PRB-binding protein E2F-1, RBAP-1, RBBP-3, retinoblastoma-associated protein 1, retinoblastoma-binding protein 3

Genomic Location:

Chr 20: 31727150-31737854

Description:

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most...

View Full Description

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PAX4_04 ,  TTANTCA_UNKNOWN ,  E2F1_Q4_01 ,  E2F4DP1_01 ,  GCANCTGNY_MYOD_Q6 ,  YATTNATC_UNKNOWN ,  E2F_Q6_01 ,  E2F_01 ,  E2F1_Q4 ,  GGGAGGRR_MAZ_Q6 ,  RYTGCNWTGGNR_UNKNOWN ,  SOX9_B1 ,  DBP_Q6 ,  E2F_Q6 ,  E2F1_Q6_01 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  E2F_Q4 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  E2F1_Q3_01 ,  TGTTTGY_HNF3_Q6 ,  SOX5_01 ,  E2F_03 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  AREB6_03 ,  RNGTGGGC_UNKNOWN ,  AP4_Q6_01 ,  E2F1DP1RB_01 ,  HEN1_02 ,  E2F_02 ,  SREBP_Q3 ,  TGCTTTG_MIR330 ,  AGGGCAG_MIR18A ,  E2F1_Q3 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  E2F4DP2_01 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  AP4_Q5 ,  E2F_Q3 ,  ATGAAGG_MIR205 ,  E2F_Q3_01 ,  GTTRYCATRR_UNKNOWN ,  PAX4_01 ,  CACTTTG_MIR520G_MIR520H ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01 ,  LMO2COM_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-330

miRNA binding sites
(Source: miRecords):

hsa-miR-17 Targeted Genes ,  hsa-miR-20a Targeted Genes ,  [miR-106b] Targeted Genes ,  [miR-20a] Targeted Genes ,  [miR-93] Targeted Genes

Cytogenetic Map:

20q11.22

search → result