QuickView for E2F6 (gene)

Gene Symbol:

E2F6 Homo sapiens

Full name:

E2F transcription factor 6

Synonyms:

E2F-6, transcription factor E2F6

Genomic Location:

Chr 2: 11501952-11523748

Description:

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcript...

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This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  HNF1_01 ,  ATGTACA_MIR493 ,  ACTGTGA_MIR27A_MIR27B ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TGCGCANK_UNKNOWN ,  TGCCTTA_MIR124A ,  NRF1_Q6 ,  YY1_02 ,  GGCCAGT_MIR193A_MIR193B

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137

miRNA binding sites
(Source: miRecords):

hsa-miR-137 Targeted Genes ,  hsa-miR-193a-3p Targeted Genes

Cytogenetic Map:

2p25.1

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