QuickView for ECT2 (gene)
- Gene Symbol:
- ECT2
Homo sapiens - Full name:
- epithelial cell transforming 2
- Synonyms:
- ARHGEF31, protein ECT2, epithelial cell-transforming sequence 2 oncogene
- Genomic Location:
- Chr 3: 173951336-174021957
- Description:
-
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3q26.31
GO Molecular Function
Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | enzyme activator activity | GTPase binding | Rho GTPase binding | GTPase activator activity | enzyme binding | GTPase regulator activity | Ras GTPase binding | molecular function regulator | identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | enzyme regulator activity
GO Biological Process
mitotic cytokinesis | protein homooligomerization | response to radiation | cell morphogenesis | Rho guanyl-nucleotide exchange factor activity | regulation of cell cycle process | activation of GTPase activity | regulation of intracellular protein transport | guanyl-nucleotide exchange factor activity | regulation of neurogenesis | regulation of cellular localization | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | positive regulation of developmental process | response to metal ion | regulation of protein import | cell differentiation | nervous system development | response to drug | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | response to antibiotic | positive regulation of GTPase activity | regulation of attachment of spindle microtubules to kinetochore | regulation of chromosome segregation | cellular process | localization | protein transport | cytoskeleton-dependent cytokinesis | GTPase activator activity | positive regulation of protein kinase activity | macromolecule localization | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | response to inorganic substance | regulation of cell differentiation | cell junction assembly | positive regulation of cytokinesis | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | cellular response to metal ion | regulation of cell division | response to stimulus | regulation of cellular protein localization | positive regulation of protein metabolic process | GTPase regulator activity | response to stress | positive regulation of cellular protein localization | cellular response to inorganic substance | cellular response to toxic substance | regulation of protein transport | G-protein coupled receptor signaling pathway | cellular component assembly | regulation of peptide transport | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | system development | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | protein complex oligomerization | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | organic substance transport | cellular response to stress | cell cycle | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | apical junction assembly | peptide transport | positive regulation of intracellular signal transduction | response to oxidative stress | bicellular tight junction assembly | positive regulation of hydrolase activity | positive regulation of cell differentiation | regulation of Rho protein signal transduction | positive regulation of protein localization to nucleus | cell division | regulation of cellular protein metabolic process | cytokinesis | response to toxic substance | regulation of GTPase activity | cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cytokinesis | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of transport | positive regulation of molecular function | regulation of nucleocytoplasmic transport | protein-containing complex assembly | regulation of establishment of protein localization | positive regulation of protein modification process | cellular response to calcium ion | regulation of protein import into nucleus | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | mitotic cell cycle | positive regulation of neurogenesis | positive regulation of cell development | cell-cell junction assembly | amide transport | cellular response to hydrogen peroxide | Ras guanyl-nucleotide exchange factor activity | positive regulation of cell death | cellular response to reactive oxygen species | response to reactive oxygen species | positive regulation of programmed cell death | positive regulation of kinase activity | cellular response to ionizing radiation | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of intracellular transport | positive regulation of protein transport | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | enzyme regulator activity | regulation of Ras protein signal transduction | anatomical structure morphogenesis | positive regulation of protein import into nucleus | regulation of nervous system development | regulation of developmental process | developmental process | positive regulation of protein import | positive regulation of cell cycle process | regulation of transport | response to calcium ion | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of protein localization | regulation of cell death | positive regulation of nucleocytoplasmic transport | regulation of I-kappaB kinase/NF-kappaB signaling | response to ionizing radiation | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
occluding junction | cleavage furrow | intracellular membrane-bounded organelle | cell | cytoplasm | spindle | intracellular organelle | cell-cell junction | protein-containing complex | centralspindlin complex | plasma membrane | midbody | microtubule cytoskeleton | membrane-bounded organelle | apical junction complex | nucleus | organelle | cell division site | cell periphery | bicellular tight junction | cytosol | cytoskeleton | intracellular | cell junction | mitotic spindle | membrane
