QuickView for EDA2R;jsessionid=E10958033198F1D4407FD5100F9BBB26 (gene)
- Gene Symbol:
- EDA2R
Homo sapiens - Full name:
- ectodysplasin A2 receptor
- Synonyms:
- EDA-A2R, EDAA2R, TNFRSF27, XEDAR, tumor necrosis factor receptor superfamily member 27, EDA-A2 receptor, X-linked ectodysplasin-A2 receptor, ectodysplasin A2 isoform receptor, tumor necrosis factor receptor superfamily member XEDAR
- Genomic Location:
- Chr X: 65732204-65752598
- Description:
-
The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcri...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
Xq12
GO Molecular Function
transmembrane signaling receptor activity | death receptor activity | signaling receptor activity | protein binding | tumor necrosis factor-activated receptor activity
GO Biological Process
response to cytokine | intracellular signal transduction | positive regulation of DNA-binding transcription factor activity | cellular response to tumor necrosis factor | cell differentiation | positive regulation of phosphate metabolic process | cellular process | positive regulation of nitrogen compound metabolic process | tissue development | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of cellular protein metabolic process | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of protein metabolic process | ectodermal cell differentiation | programmed cell death | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | regulation of signal transduction | multicellular organism development | regulation of MAPK cascade | regulation of phosphorylation | regulation of gene expression | death receptor activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | epidermis development | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of RNA metabolic process | apoptotic signaling pathway | positive regulation of molecular function | positive regulation of protein modification process | response to organic substance | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | cell death | tumor necrosis factor-activated receptor activity | positive regulation of NF-kappaB transcription factor activity | tumor necrosis factor-mediated signaling pathway | regulation of phosphate metabolic process | intrinsic apoptotic signaling pathway by p53 class mediator | ectoderm development | regulation of JNK cascade | positive regulation of MAPK cascade | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | developmental process | positive regulation of metabolic process | response to tumor necrosis factor | cellular response to organic substance | signal transduction by p53 class mediator | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | plasma membrane | integral component of plasma membrane | cell periphery | intracellular | membrane | intrinsic component of plasma membrane
