QuickView for EFNA1 (gene)

Gene Symbol:

EFNA1 Homo sapiens

Full name:

ephrin A1

Synonyms:

B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, ephrin-A1, TNF alpha-induced protein 4, eph-related receptor tyrosine kinase ligand 1, immediate early response protein B61, ligand of eph-related kinase 1, tumor necrosis factor, alpha-induced protein 4

Genomic Location:

Chr 1: 153366973-153374010

Description:

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided...

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This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  MAZR_01 ,  TGANTCA_AP1_C ,  MYOD_01 ,  MAZ_Q6 ,  AREB6_02 ,  FOX_Q2 ,  GCANCTGNY_MYOD_Q6 ,  AAAYWAACM_HFH4_01 ,  AACTGAC_MIR223 ,  AREB6_04 ,  SRY_01 ,  AP1_Q6 ,  FAC1_01 ,  GR_Q6_01 ,  RFX1_01 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  AP1_Q6_01 ,  SOX9_B1 ,  LEF1_Q6 ,  FOXO3_01 ,  CAGGTG_E12_Q6 ,  AP1FJ_Q2 ,  MYOD_Q6 ,  BACH2_01 ,  AP1_Q2_01 ,  NERF_Q2 ,  E47_01 ,  TGTTTGY_HNF3_Q6 ,  AP1_Q4 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  AP4_Q6_01 ,  AAAYRNCTG_UNKNOWN ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  RGAGGAARY_PU1_Q6 ,  AP1_Q2 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  MZF1_02 ,  FOXO4_02 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

1q22

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