QuickView for EGF (gene)

Gene Symbol:

EGF Homo sapiens

Full name:

epidermal growth factor

Synonyms:

HOMG4, URG, pro-epidermal growth factor, beta-urogastrone

Genomic Location:

Chr 4: 111053499-111152868

Description:

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein ac...

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This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  STAT4_01 ,  STAT6_02 ,  NFKAPPAB_01 ,  STAT1_03 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  TATA_C ,  CTTTAAR_UNKNOWN ,  HSF2_01 ,  NFKB_Q6_01 ,  AACTTT_UNKNOWN ,  GGARNTKYCCA_UNKNOWN ,  NFKB_C

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Cytogenetic Map:

4q25

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