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QuickView for EGR1;jsessionid=7D1D703D6C2B949600F429147F686899 (gene)


Gene Symbol:
EGR1 Homo sapiens Homo sapiens
Full name:
early growth response 1
Synonyms:
AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response protein 1, EGR-1, nerve growth factor-induced protein A, transcription factor ETR103, transcription factor Zif268, zinc finger protein 225, zinc finger protein Krox-24
Genomic Location:
Chr 5: 137829080-137832903
Description:
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Bos taurus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q31.2


Transcripts Names
NM_001964
Protein Names
P18146
Q546S1



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | enzyme binding | nucleic acid binding | hemi-methylated DNA-binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | zinc ion binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | double-stranded methylated DNA binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | regulation of interleukin-1 beta production | positive regulation of cell proliferation involved in kidney development | response to radiation | cellular response to mycophenolic acid | positive regulation of hormone biosynthetic process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | response to cytokine | response to interleukin-1 | muscle tissue development | cellular response to interleukin-8 | cell proliferation involved in kidney development | regulation of programmed cell death | cellular response to type I interferon | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | defense response | glomerulus development | response to drug | positive regulation of tau-protein kinase activity | positive regulation of phosphate metabolic process | response to antibiotic | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glomerulus development | lymphocyte differentiation | response to type I interferon | regulation of cytokine biosynthetic process | negative regulation of signaling | immune system development | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | response to hypoxia | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | muscle structure development | skeletal muscle organ development | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | urogenital system development | T cell activation | regulation of vasculature development | response to stimulus | positive regulation of interleukin-1 beta production | vasculature development | positive regulation of protein metabolic process | positive regulation of glomerular metanephric mesangial cell proliferation | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | positive regulation of chemokine biosynthetic process | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | response to peptide | response to glucose | positive regulation of cytokine biosynthetic process | reproduction | cardiovascular system development | regulation of glomerular mesangial cell proliferation | glomerular mesangial cell proliferation | rhythmic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | response to ischemia | cellular response to organic cyclic compound | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | regulation of steroid biosynthetic process | cellular biosynthetic process | kidney development | regulation of steroid metabolic process | response to mycotoxin | blood vessel development | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to nitrogen compound | response to BMP | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | glomerulus vasculature development | regulation of tau-protein kinase activity | regulation of progesterone biosynthetic process | regulation of catalytic activity | regulation of phosphorylation | regulation of hormone levels | positive regulation of interleukin-1 beta biosynthetic process | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular response to radiation | regulation of ketone biosynthetic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | interleukin-1-mediated signaling pathway | cytokine-mediated signaling pathway | regulation of transcription by RNA polymerase II | cellular response to gamma radiation | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of neuron death | positive regulation of chemokine production | response to toxic substance | response to xenobiotic stimulus | regulation of protein sumoylation | response to gamma radiation | cellular response to drug | regulation of interleukin-1 production | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cellular response to mycotoxin | transmembrane receptor protein serine/threonine kinase signaling pathway | positive regulation of interleukin-1 production | metanephros development | regulation of protein metabolic process | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | regulation of RNA metabolic process | renal system development | regulation of lipid biosynthetic process | nephron development | lymphocyte activation | positive regulation of molecular function | multicellular organism reproduction | T cell differentiation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to antineoplastic agent | positive regulation of metanephric glomerulus development | cellular response to heparin | response to insulin | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of kinase activity | cellular response to ionizing radiation | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | response to anticoagulant | transcription, DNA-templated | positive regulation of cytokine production | cell activation | positive regulation of interleukin-1 biosynthetic process | estrous cycle | BMP signaling pathway | type I interferon signaling pathway | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | positive regulation of phosphorylation | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cytokine production | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | negative regulation of canonical Wnt signaling pathway | positive regulation of glomerular mesangial cell proliferation | cellular response to interleukin-1 | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | cellular response to BMP stimulus | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | response to carbohydrate | circulatory system development | skeletal muscle cell differentiation | response to ionizing radiation | muscle organ development | response to heparin | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of hormone biosynthetic process | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular