QuickView for EHMT1 (gene)

Gene Symbol:

EHMT1 Homo sapiens

Full name:

euchromatic histone lysine methyltransferase 1

Synonyms:

EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D, histone-lysine N-methyltransferase EHMT1, EHMT1 intronic transcript 1, G9a-like protein 1, H3-K9-HMTase 5, euchromatic histone-lysine N-methyltransferase 1, histone H3-K9 methyltransferase 5, histone-lysine N-methyltransferase, H3 lysine-9 specific 5, lysine N-methyltransferase 1D

Genomic Location:

Chr 9: 139725238-139850400

Description:

The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 ...

View Full Description

The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  WTGAAAT_UNKNOWN ,  GCACCTT_MIR18A_MIR18B ,  AACATTC_MIR4093P ,  ACCATTT_MIR522 ,  MYB_Q3

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-409-3p

Cytogenetic Map:

9q34.3

search → result