QuickView for EIF2A;jsessionid=CB04978FB0DC8B5BD46DEB87AC215E6B (gene)

Gene Symbol:

EIF2A Homo sapiens

Full name:

eukaryotic translation initiation factor 2A

Synonyms:

CDA02, EIF-2A, MST089, MSTP004, MSTP089, eukaryotic translation initiation factor 2A, 65 kDa eukaryotic translation initiation factor 2A, eukaryotic translation initiation factor 2A, 65kDa

Genomic Location:

Chr 3: 151747264-151786493

Description:

This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initi...

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This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGNNNNNNKCCAR_UNKNOWN ,  TTAYRTAA_E4BP4_01 ,  GGGAGGRR_MAZ_Q6 ,  NF1_Q6_01 ,  YGCGYRCGC_UNKNOWN ,  RCGCANGCGY_NRF1_Q6 ,  ACCATTT_MIR522

Cytogenetic Map:

3q25.1

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