QuickView for EPAS1 (gene)

Gene Symbol:

EPAS1 Homo sapiens

Full name:

endothelial PAS domain protein 1

Synonyms:

ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73, endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2-alpha, HIF2-alpha, PAS domain-containing protein 2, basic-helix-loop-helix-PAS protein MOP2, class E basic helix-loop-helix protein 73, hypoxia-inducible factor 2 alpha, member of PAS protein 2

Genomic Location:

Chr 2: 46378067-46467340

Description:

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene...

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This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  YGACNNYACAR_UNKNOWN ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TCTGATC_MIR383 ,  ACTTTAT_MIR1425P ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  TATA_C ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  TTGCCAA_MIR182 ,  AAGCACT_MIR520F ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

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Cytogenetic Map:

2p21

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