QuickView for EPHA2;jsessionid=6D3E08C58BAFEDA659A1F338CEF9EC38 (gene)

Gene Symbol:

EPHA2 Homo sapiens

Full name:

EPH receptor A2

Synonyms:

ARCC2, CTPA, CTPP1, CTRCT6, ECK, ephrin type-A receptor 2, epithelial cell receptor protein tyrosine kinase, soluble EPHA2 variant 1, tyrosine-protein kinase receptor ECK

Genomic Location:

Chr 1: 16323419-16355151

Description:

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibron...

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This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  MYOD_Q6_01 ,  AP1_C ,  TGANTCA_AP1_C ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  RYTTCCTG_ETS2_B ,  MAZ_Q6 ,  NFAT_Q6 ,  STAT6_02 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  PEA3_Q6 ,  ATF4_Q2 ,  LYF1_01 ,  CAGTGTT_MIR141_MIR200A ,  TACTTGA_MIR26A_MIR26B ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  E2A_Q2 ,  MYCMAX_B ,  CREB_Q4 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  AR_Q6 ,  RGAANNTTC_HSF1_01 ,  NFE2_01 ,  AP1_Q6_01 ,  LEF1_Q2 ,  GTGACGY_E4F1_Q6 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  HSF1_01 ,  AP4_Q6 ,  ETS2_B ,  AP1FJ_Q2 ,  CREB_02 ,  ATF3_Q6 ,  STAT5A_03 ,  CTTTAAR_UNKNOWN ,  E47_01 ,  GCM_Q2 ,  AP1_Q4 ,  YCATTAA_UNKNOWN ,  GTGCCTT_MIR506 ,  CETS1P54_01 ,  ELK1_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  MYOGENIN_Q6 ,  IK2_01 ,  CREB_Q2 ,  SMAD4_Q6 ,  TGACGTCA_ATF3_Q6 ,  KMCATNNWGGA_UNKNOWN ,  AP1_Q2 ,  CAGCTG_AP4_Q5 ,  NFKB_Q6 ,  CREB_Q2_01 ,  CREB_01 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

1p36.13

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