QuickView for EPS15;jsessionid=53CA6A2F744C5C7317278616728B444B (gene)

Gene Symbol:

EPS15 Homo sapiens

Full name:

epidermal growth factor receptor pathway substrate 15

Synonyms:

AF-1P, AF1P, MLLT5, epidermal growth factor receptor substrate 15, ALL1 fused gene from chromosome 1, protein AF-1p

Genomic Location:

Chr 1: 51592523-51757583

Description:

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_01 ,  TTTGCAC_MIR19A_MIR19B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TTGCACT_MIR130A_MIR301_MIR130B ,  MAF_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  ATACCTC_MIR202 ,  RRAGTTGT_UNKNOWN ,  ACTACCT_MIR196A_MIR196B ,  SPZ1_01 ,  SP1_Q6 ,  AATGTGA_MIR23A_MIR23B ,  SP1_Q6_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

1p32.3

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