QuickView for ER81 (gene)

Gene Symbol:

ETV1 Homo sapiens

Full name:

ETS variant 1

Synonyms:

ER81, ETS translocation variant 1, ets variant gene 1, ets-related protein 81

Genomic Location:

Chr 7: 13897379-13995289

Description:

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-...

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This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  POU6F1_01 ,  AACWWCAANK_UNKNOWN ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  TTTGCAC_MIR19A_MIR19B ,  SMTTTTGT_UNKNOWN ,  PU1_Q6 ,  GATA1_03 ,  OCT1_B ,  MYOD_01 ,  GCATTTG_MIR105 ,  ARNT_01 ,  OCT1_04 ,  P53_DECAMER_Q2 ,  HFH3_01 ,  OCT1_01 ,  AP3_Q6 ,  FOXO4_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  GATA_C ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  CTACTGT_MIR199A ,  GCANCTGNY_MYOD_Q6 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  MAX_01 ,  WGTTNNNNNAAA_UNKNOWN ,  CAGCACT_MIR5123P ,  AMEF2_Q6 ,  ACTTTAT_MIR1425P ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  GGGCATT_MIR365 ,  GCCATNTTG_YY1_Q6 ,  OCT1_Q5_01 ,  OCT_C ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  MYCMAX_02 ,  OCT1_Q6 ,  CEBPB_01 ,  SOX9_B1 ,  TTGGAGA_MIR5155P_MIR519E ,  PAX4_02 ,  CATTTCA_MIR203 ,  TITF1_Q3 ,  YY1_Q6 ,  LFA1_Q6 ,  FREAC3_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  HNF4_Q6 ,  RRAGTTGT_UNKNOWN ,  TGCCTTA_MIR124A ,  MYCMAX_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GCAAAAA_MIR129 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  TGCTGAY_UNKNOWN ,  USF_C ,  S8_01 ,  FOXO1_01 ,  PAX6_01 ,  HFH4_01 ,  MEIS1_01 ,  HFH8_01 ,  USF_01 ,  NCX_01 ,  AATGTGA_MIR23A_MIR23B ,  NMYC_01 ,  CHX10_01 ,  USF_Q6_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  ATATGCA_MIR448 ,  CEBP_C ,  IK2_01 ,  RTTTNNNYTGGM_UNKNOWN ,  GATA1_05 ,  CP2_02 ,  CTGCAGY_UNKNOWN ,  CREL_01 ,  GGCCAGT_MIR193A_MIR193B ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  NFKB_Q6_01 ,  CAGCTG_AP4_Q5 ,  CCAATNNSNNNGCG_UNKNOWN ,  AACTTT_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  USF_02 ,  ACCATTT_MIR522 ,  GGGNNTTTCC_NFKB_Q6_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-20

Cytogenetic Map:

7p21.2

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