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QuickView for ERBB2 (gene)


Gene Symbol:
ERBB2 Homo sapiens Homo sapiens
Full name:
erb-b2 receptor tyrosine kinase 2
Synonyms:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, receptor tyrosine-protein kinase erbB-2, c-erb B2/neu protein, herstatin, human epidermal growth factor receptor 2, metastatic lymph node gene 19 protein, neuro/glioblastoma derived oncogene homolog, neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2, proto-oncogene Neu, proto-oncogene c-ErbB-2, tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2, v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Genomic Location:
Chr 17: 35097919-35138441
Description:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing k...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 17
17q12





GO Molecular Function

guanyl-nucleotide exchange factor activity | transmembrane receptor protein tyrosine kinase activity | GTPase binding | RNA polymerase binding | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | Ras GTPase binding | growth factor binding | molecular function regulator | catalytic activity | ErbB-3 class receptor binding | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | RNA polymerase core enzyme binding | phosphatidylinositol 3-kinase activity | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | RNA polymerase I core binding | protein phosphatase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding

GO Biological Process

negative regulation of lymphocyte differentiation | RNA metabolic process | negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | cell morphogenesis | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | negative regulation of immune system process | guanyl-nucleotide exchange factor activity | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | phosphatidylinositol metabolic process | regulation of transcription by RNA polymerase I | regulation of immune system process | regulation of immature T cell proliferation in thymus | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | regulation of MAP kinase activity | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | regulation of T cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | phospholipid metabolic process | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | peripheral nervous system development | regulation of cell motility | axon ensheathment | cell projection morphogenesis | negative regulation of signaling | neuron development | positive regulation of protein kinase activity | negative regulation of apoptotic process | axon guidance | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | regulation of transcription by RNA polymerase III | regulation of cell differentiation | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | cellular lipid metabolic process | MAPK cascade | regulation of vasculature development | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | response to stress | neuron projection guidance | negative regulation of lymphocyte activation | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | ensheathment of neurons | phosphatidylinositol-mediated signaling | positive regulation of transcription by RNA polymerase III | cellular nitrogen compound metabolic process | ERBB signaling pathway | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | negative regulation of immature T cell proliferation | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | regulation of intracellular transport | molecular function regulator | ERBB2 signaling pathway | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | locomotion | system development | nitrogen compound metabolic process | regulation of signal transduction | myelination | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | wound healing | regulation of T cell activation | regulation of gene expression | axon development | positive regulation of intracellular protein transport | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | neuromuscular junction development | protein autophosphorylation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of transcription by RNA polymerase II | phosphatidylinositol 3-kinase activity | synapse organization | axonogenesis | positive regulation of hydrolase activity | negative regulation of immature T cell proliferation in thymus | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | glial cell differentiation | phosphorylation | inositol lipid-mediated signaling | regulation of GTPase activity | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | lipid phosphorylation | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | heart development | lipid modification | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | negative regulation of T cell differentiation | regulation of microtubule-based process | protein tyrosine kinase activity | positive regulation of molecular function | cellular response to epidermal growth factor stimulus | neuron differentiation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of hemopoiesis | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of protein targeting | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | oligodendrocyte differentiation | Ras guanyl-nucleotide exchange factor activity | nucleobase-containing compound metabolic process | negative regulation of ERBB signaling pathway | protein kinase activity | neuron projection development | organic substance metabolic process | animal organ development | gene expression | regulation of cell activation | positive regulation of transcription by RNA polymerase I | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | transcription, DNA-templated | positive regulation of intracellular transport | positive regulation of MAPK cascade | response to epidermal growth factor | positive regulation of protein transport | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | cell development | regulation of ERBB signaling pathway | regulation of T cell proliferation | regulation of epithelial cell proliferation | regulation of T cell differentiation in thymus | positive regulation of phosphorylation | cellular protein metabolic process | phosphatidylinositol phosphorylation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | developmental process | regulation of cell growth | cellular protein modification process | positive regulation of protein targeting to membrane | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of lymphocyte proliferation | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of translation | negative regulation of cell death | circulatory system development | chemotaxis | negative regulation of T cell differentiation in thymus | motor neuron axon guidance | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | basal plasma membrane | intracellular membrane-bounded organelle | apical plasma membrane | organelle membrane | cytoplasmic vesicle | basal part of cell | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | apical part of cell | endosome membrane | protein-containing complex | endomembrane system | plasma membrane | vesicle | perinuclear region of cytoplasm | integral component of plasma membrane | endosome | membrane-bounded organelle | nucleus | organelle | cell periphery | basolateral plasma membrane | cytosol | intracellular vesicle | intracellular | myelin sheath | membrane | intrinsic component of plasma membrane