QuickView for ERC1;jsessionid=E10958033198F1D4407FD5100F9BBB26 (gene)
- Gene Symbol:
- ERC1
Homo sapiens - Full name:
- ELKS/RAB6-interacting/CAST family member 1
- Synonyms:
- Cast2, ELKS, ERC-1, RAB6IP2, ELKS/Rab6-interacting/CAST family member 1, RAB6 interacting protein 2
- Genomic Location:
- Chr 12: 970665-1472958
- Description:
-
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing res...
- Orthologs:
- Mus musculus , Rattus norvegicus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12p13.33
GO Molecular Function
GTPase binding | cadherin binding | enzyme binding | Ras GTPase binding | protein domain specific binding | cell adhesion molecule binding | protein binding | small GTPase binding | Rab GTPase binding | leucine zipper domain binding | LRR domain binding | PDZ domain binding
GO Biological Process
intracellular signal transduction | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | intracellular transport | cellular process | localization | protein transport | I-kappaB phosphorylation | macromolecule localization | negative regulation of apoptotic process | establishment of localization in cell | cytosolic transport | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | response to stimulus | endosomal transport | cellular localization | protein modification process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | multicellular organism development | phosphorus metabolic process | regulation of gene expression | organic substance transport | regulation of nitrogen compound metabolic process | peptide transport | vesicle-mediated transport | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | positive regulation of molecular function | protein metabolic process | regulation of DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | amide transport | organic substance metabolic process | positive regulation of NF-kappaB transcription factor activity | retrograde transport, endosome to Golgi | establishment of protein localization | signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | protein localization | cellular protein metabolic process | developmental process | cellular protein modification process | cellular metabolic process | regulation of cell death | negative regulation of cell death | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
presynaptic membrane | intracellular membrane-bounded organelle | synapse | catalytic complex | organelle membrane | protein kinase complex | cell | synaptic membrane | cytoplasm | intracellular organelle | presynapse | IkappaB kinase complex | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | transferase complex | Golgi membrane | serine/threonine protein kinase complex | membrane-bounded organelle | organelle | presynaptic active zone | cell periphery | cytosol | intracellular | membrane
