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QuickView for ESR2 (gene)


Gene Symbol:
ESR2 Homo sapiens Homo sapiens
Full name:
estrogen receptor 2
Synonyms:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2, estrogen receptor beta, estrogen receptor beta 4, nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Genomic Location:
Chr 14: 63763504-63875021
Description:
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded prote...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 14
14q23.2-q23.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | receptor antagonist activity | nuclear receptor activity | cation binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | lipid binding | receptor inhibitor activity | signaling receptor binding | steroid hormone receptor activity | molecular function regulator | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | identical protein binding | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | estrogen receptor activity | protein binding | zinc ion binding | receptor regulator activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | estrogen response element binding | RNA polymerase II regulatory region sequence-specific DNA binding | transition metal ion binding | steroid binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | negative regulation of signaling receptor activity | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | positive regulation of DNA-binding transcription factor activity | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | receptor antagonist activity | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | negative regulation of signaling | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | receptor inhibitor activity | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | cell-cell signaling | molecular function regulator | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | regulation of gene expression | response to lipid | extracellular negative regulation of signal transduction | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | intracellular estrogen receptor signaling pathway | regulation of transcription by RNA polymerase II | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | estrogen receptor activity | negative regulation of cell growth | positive regulation of molecular function | regulation of signaling receptor activity | receptor regulator activity | DNA-binding transcription factor activity | regulation of growth | response to organic substance | regulation of DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular macromolecule biosynthetic process | regulation of cell growth | intracellular steroid hormone receptor signaling pathway | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | response to steroid hormone | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | extracellular region | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular