QuickView for ETV6 (gene)

Gene Symbol:

ETV6 Homo sapiens

Full name:

ETS variant 6

Synonyms:

TEL, TEL/ABL, THC5, transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, TEL1 oncogene, ets variant gene 6 (TEL oncogene)

Genomic Location:

Chr 12: 11694055-11939603

Description:

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and mainte...

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This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TFIIA_Q6 ,  CREBP1CJUN_01 ,  ATF6_01 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  HOXA4_Q2 ,  TTGCWCAAY_CEBPB_02 ,  LXR_DR4_Q3 ,  YNTTTNNNANGCARM_UNKNOWN ,  CEBP_Q2_01 ,  YATTNATC_UNKNOWN ,  NFKAPPAB_01 ,  STAT6_01 ,  ZIC3_01 ,  GR_Q6_01 ,  TGACCTY_ERR1_Q2 ,  LEF1_Q6 ,  PAX4_02 ,  GCACCTT_MIR18A_MIR18B ,  CTCAGGG_MIR125B_MIR125A ,  GTCAGGA_MIR378 ,  WYAAANNRNNNGCG_UNKNOWN ,  AACYNNNNTTCCS_UNKNOWN ,  STAT5A_03 ,  GATA6_01 ,  CCCNNGGGAR_OLF1_01 ,  IRF_Q6 ,  CTTTAAR_UNKNOWN ,  GCCNNNWTAAR_UNKNOWN ,  PTF1BETA_Q6 ,  AGGGCCA_MIR328 ,  AR_Q2 ,  NCX_01 ,  TAATTA_CHX10_01 ,  IK3_01 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  PAX_Q6 ,  GGCCAGT_MIR193A_MIR193B ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  AACTTT_UNKNOWN ,  TCF1P_Q6 ,  ETS1_B ,  TCATCTC_MIR143 ,  STTTCRNTTT_IRF_Q6 ,  HNF4_01_B ,  TATTATA_MIR374 ,  CCTNTMAGA_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

12p13.2

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