QuickView for EXOSC9;jsessionid=3AF6582FCE9B76A30AFDE2755BDF2B68 (gene)
- Gene Symbol:
- EXOSC9
Homo sapiens - Full name:
- exosome component 9
- Synonyms:
- PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, exosome complex component RRP45, P75 polymyositis-scleroderma overlap syndrome associated autoantigen, PMSCL autoantigen, 75kD, autoantigen PM/Scl 1, exosome complex exonuclease RRP45, polymyositis/scleroderma autoantigen 1, 75kDa
- Genomic Location:
- Chr 4: 122941922-122957626
- Description:
-
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Canis lupus familiaris , Bos taurus , Gallus gallus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
4q27
GO Molecular Function
nuclease activity | 3'-5'-exoribonuclease activity | RNA polymerase II activating transcription factor binding | nucleic acid binding | exoribonuclease activity | hydrolase activity | ribonuclease activity | catalytic activity | hydrolase activity, acting on ester bonds | exoribonuclease activity, producing 5'-phosphomonoesters | AU-rich element binding | organic cyclic compound binding | protein binding | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | 3'-5' exonuclease activity | exonuclease activity | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | RNA surveillance | positive regulation of macromolecule biosynthetic process | snRNA metabolic process | RNA processing | nuclease activity | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 3'-5'-exoribonuclease activity | nuclear-transcribed mRNA catabolic process, exonucleolytic | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | maturation of 5.8S rRNA | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | polyadenylation-dependent mRNA catabolic process | regulation of mRNA stability | regulation of cellular process | positive regulation of cell growth | regulation of metabolic process | catabolic process | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | mRNA catabolic process | exoribonuclease activity | response to stimulus | posttranscriptional regulation of gene expression | ncRNA 3'-end processing | ncRNA processing | cellular nitrogen compound metabolic process | nuclear RNA surveillance | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | mRNA metabolic process | ribonuclease activity | nuclear-transcribed mRNA catabolic process | nucleobase-containing compound catabolic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | tRNA catabolic process | nuclear polyadenylation-dependent tRNA catabolic process | U4 snRNA 3'-end processing | regulation of gene expression | RNA catabolic process | positive regulation of cellular metabolic process | nuclear polyadenylation-dependent ncRNA catabolic process | regulation of nitrogen compound metabolic process | regulation of RNA stability | nuclear mRNA surveillance | regulation of transcription by RNA polymerase II | nuclear polyadenylation-dependent rRNA catabolic process | cleavage involved in rRNA processing | exoribonuclease activity, producing 5'-phosphomonoesters | U5 snRNA 3'-end processing | rRNA metabolic process | rRNA catabolic process | regulation of cellular metabolic process | snRNA processing | aromatic compound catabolic process | polyadenylation-dependent RNA catabolic process | regulation of RNA metabolic process | rRNA processing | tRNA metabolic process | snRNA 3'-end processing | regulation of growth | rRNA 3'-end processing | cellular macromolecule catabolic process | metabolic process | RNA 3'-end processing | regulation of RNA biosynthetic process | 3'-5' exonuclease activity | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | regulation of mRNA catabolic process | RNA phosphodiester bond hydrolysis | gene expression | RNA phosphodiester bond hydrolysis, exonucleolytic | positive regulation of growth | regulation of transcription, DNA-templated | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | regulation of cell growth | U1 snRNA 3'-end processing | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' | exonuclease activity | positive regulation of transcription, DNA-templated | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | ribonucleoprotein complex biogenesis | nuclear polyadenylation-dependent mRNA catabolic process | immune system process | cellular metabolic process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | exosome (RNase complex) | nuclear exosome (RNase complex) | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | nuclear chromosome | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytoplasmic exosome (RNase complex) | cytosol | intracellular
