QuickView for EZH2 (gene)

Gene Symbol:

EZH2 Homo sapiens

Full name:

enhancer of zeste 2 polycomb repressive complex 2 subunit

Synonyms:

ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS, WVS2, histone-lysine N-methyltransferase EZH2, enhancer of zeste homolog 2, lysine N-methyltransferase 6

Genomic Location:

Chr 7: 148135408-148212347

Description:

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear...

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This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATGCAGT_MIR217 ,  MAZR_01 ,  E2F1_Q4_01 ,  E2F4DP1_01 ,  GCANCTGNY_MYOD_Q6 ,  E2F_Q6_01 ,  WGTTNNNNNAAA_UNKNOWN ,  GTACTGT_MIR101 ,  TACTTGA_MIR26A_MIR26B ,  TTF1_Q6 ,  E2F1_Q4 ,  E2F_Q6 ,  E2F1_Q6_01 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  CACCAGC_MIR138 ,  E2F_Q4 ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  E2F1_Q3_01 ,  E2F_03 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F1_Q3 ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  KTGGYRSGAA_UNKNOWN ,  E2F_Q3 ,  E2F_Q3_01 ,  RRCCGTTA_UNKNOWN ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-378

miRNA binding sites
(Source: miRecords):

hsa-miR-101 Targeted Genes

Cytogenetic Map:

7q36.1

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