QuickView for En1 (gene)

Gene Symbol:

EN1 Homo sapiens

Full name:

engrailed homeobox 1

Synonyms:

homeobox protein engrailed-1, engrailed homolog 1, homeobox protein en-1, hu-En-1

Genomic Location:

Chr 2: 119316217-119322229

Description:

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that ...

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Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  IRF1_01 ,  OCT1_07 ,  PAX4_04 ,  FREAC7_01 ,  SMTTTTGT_UNKNOWN ,  GCGSCMNTTT_UNKNOWN ,  TGIF_01 ,  TGANTCA_AP1_C ,  CEBPA_01 ,  GATA1_03 ,  TTANTCA_UNKNOWN ,  MZF1_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GATA3_01 ,  HEN1_01 ,  GATA_Q6 ,  GATA_C ,  CACGTG_MYC_Q2 ,  GAGACTG_MIR452 ,  MAX_01 ,  YATTNATC_UNKNOWN ,  WGTTNNNNNAAA_UNKNOWN ,  STAT6_01 ,  ARNT_02 ,  GATAAGR_GATA_C ,  SREBP1_Q6 ,  CTTTGA_LEF1_Q2 ,  STAT1_03 ,  GATA1_04 ,  HEB_Q6 ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  MYCMAX_02 ,  GGATTA_PITX2_Q2 ,  AP4_01 ,  YY1_01 ,  LHX3_01 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  LMO2COM_02 ,  AP1_Q2_01 ,  OCT1_03 ,  HIF1_Q5 ,  E2F1_Q3_01 ,  NKX61_01 ,  NKX25_02 ,  CTTTAAR_UNKNOWN ,  HFH4_01 ,  POU1F1_Q6 ,  MEIS1_01 ,  GATA1_02 ,  OCT1_06 ,  HMGIY_Q6 ,  FREAC2_01 ,  BACH1_01 ,  CHX10_01 ,  CETS1P54_01 ,  ELK1_01 ,  USF_Q6_01 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  CART1_01 ,  SCGGAAGY_ELK1_02 ,  MSX1_01 ,  GATA1_05 ,  IRF7_01 ,  YTAATTAA_LHX3_01 ,  SREBP_Q3 ,  PAX_Q6 ,  TGACAGNY_MEIS1_01 ,  TBP_01 ,  TAANNYSGCG_UNKNOWN ,  CAGCTG_AP4_Q5 ,  SMAD_Q6 ,  ELK1_02 ,  ZF5_B ,  CCAATNNSNNNGCG_UNKNOWN ,  PAX2_02 ,  AP1_Q4_01 ,  HIF1_Q3 ,  TATTATA_MIR374 ,  SP1_Q2_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-491

Cytogenetic Map:

2q14.2

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