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QuickView for Ephedrine (compound)


PubChem
Name: Ephedrine
PubChem Compound ID: 11972440
Description: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Molecular formula: C10H15NO
Molecular weight: 165.232 g/mol
Synonyms:
D-Pseudoephedrine
DrugBank
Identification
Name: Ephedrine
Name (isomeric): DB01364
Drug Type: small molecule
Description: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Category: Adrenergic Agents, Sympathomimetics, Vasoconstrictor Agents, Central Nervous System Stimulants
CAS number: 299-42-3
Pharmacology
Indication: Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
Pharmacology: Ephedrine is similar in structure to the derivatives amphetamine and methamphetamine. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It works mainly by increasing the activity of noradrenaline on adrenergic receptors.
Mechanism of Action:
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic α-receptors and β-receptors, b...
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Absorption: 85%
Route of elimination: mainly renal
Half Life: 3-6 hours
Toxicity: Cardiovascular: tachycardia, cardiac arrhythmias, angina pectoris, vasoconstriction with hypertension
Interactions
Drug interaction:
AmitriptylineThe tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of ephedrine.
PhenelzineIncreased arterial pressure
AmoxapineThe tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of ephedrine.
MoclobemideMoclobemide increases the sympathomimetic effect of ephedrine.
IsocarboxazidIncreased arterial pressure
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Targets