QuickView for ErbB3 (gene)

Gene Symbol:

ERBB3 Homo sapiens

Full name:

erb-b2 receptor tyrosine kinase 3

Synonyms:

ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, receptor tyrosine-protein kinase erbB-3, human epidermal growth factor receptor 3, proto-oncogene-like protein c-ErbB-3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Genomic Location:

Chr 12: 54760159-54783395

Description:

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with...

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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MYOD_Q6_01 ,  HNF4ALPHA_Q6 ,  GATA1_03 ,  MYOD_01 ,  ZIC1_01 ,  AREB6_02 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  AREB6_04 ,  ZIC3_01 ,  HEB_Q6 ,  HNF4_DR1_Q3 ,  GGGAGGRR_MAZ_Q6 ,  HNF4_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  E47_02 ,  ZID_01 ,  HNF4_Q6 ,  MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  AREB6_03 ,  GGCAGCT_MIR22 ,  TTGTTT_FOXO4_01 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  TGACATY_UNKNOWN ,  DR4_Q2 ,  ATGAAGG_MIR205 ,  TCATCTC_MIR143 ,  SP1_Q2_01 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-378

miRNA binding sites
(Source: miRecords):

hsa-miR-125a-5p Targeted Genes ,  hsa-miR-125b Targeted Genes

Cytogenetic Map:

12q13.2

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