QuickView for ErbB4 (gene)

Gene Symbol:

ERBB4 Homo sapiens

Full name:

erb-b2 receptor tyrosine kinase 4

Synonyms:

ALS19, HER4, p180erbB4, receptor tyrosine-protein kinase erbB-4, ERBB4 transcript variant I12DEL, ERBB4 transcript variant I20DEL, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, human epidermal growth factor receptor 4, proto-oncogene-like protein c-ErbB-4, tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

Genomic Location:

Chr 2: 211948687-213111597

Description:

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is ac...

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This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  TTTGCAC_MIR19A_MIR19B ,  ZIC1_01 ,  AREB6_02 ,  AP3_Q6 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGA_LEF1_Q2 ,  AAGCAAT_MIR137 ,  PBX1_01 ,  TGACCTY_ERR1_Q2 ,  CREB_Q3 ,  COMP1_01 ,  CEBPB_01 ,  YYCATTCAWW_UNKNOWN ,  CAGGTG_E12_Q6 ,  GTCTTCC_MIR7 ,  MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  SOX5_01 ,  OCT1_06 ,  EN1_01 ,  OCT1_02 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  GGCCAGT_MIR193A_MIR193B ,  ER_Q6_01 ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ACACTGG_MIR199A_MIR199B ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

2q34

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